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Chaque projet soutenu par Gebert Rüf Stiftung est présenté sur le site web de la fondation avec en particulier les données de base du projet. Par cette publication, la fondation informe sur les résultats du soutien accordé et contribue à la communication scientifique au sein de la société.

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Peptidic Targeted Transport System

Rédaction

Für den Inhalt der Angaben zeichnet die Projektleitung verantwortlich.

Coopération

Dieses von der Gebert Rüf Stiftung geförderte Projekt wird von folgenden weiteren Projektpartnern mitgetragen: Pharmaceutical Technology, Basel; LASCCO SA, Geneva

Données de projet

  • Numéro du projet: GRS-048/11 
  • Subside accordé: CHF 336'000 
  • Consentement: 26.01.2012 
  • Durée: 08.2012 - 12.2015 
  • Champs d'activité:  Pilotprojekte, 1998 - 2018

Direction du projet

Description du projet

Gene therapy and small molecule drug delivery enables the relief and healing of diverse diseases. However, it is reliant on a nano carrier system, which allows transport to the desired location to protect against early degeneration. In this context a new nano delivery system solely based on amino acids was developed to combine both small molecule drug and DNA delivery into a system that naturally degrades to release the therapeutics. Therefore, the body’s intrinsic degradation pathways allow the delivery, release, and finally, the clearance of the nanoparticle after application. The system is convincing in terms of high drug/gene loading and functionality, but notably through the «natural» amino acids.

The goal of the project is to develop a prototype as a universal platform for the delivery of multiple drugs and DNA strands for a cooperative therapeutic effect. We will modify and optimize the carrier system to combat a neurodegenerative disease in collaboration with Lascco SA.

Quelles sont les particularités de ce projet?

The development of drug/gene delivery systems on newly designed amphiphilic peptide sequences is an emerging field of research. However, our system has the potential to work as a prototype for future developments and progress in gene therapy and combined treatments.

Etat/résultats intermédiaires

Recent investigations clarified the details in the self-assembly of our purely peptidic system into a multi compartment micelles structure. This is especially beneficial in terms of encapsulating hydrophilic and hydrophobic drugs simultaneously. The embedding of short single stranded DNA has been proven. Preliminary results confirmed responsiveness of a release mechanism, ability to simultaneously load multiple cargoes, and showed promising results for enhancing the delivery of drugs without toxicity.

The collaboration with the Pharmaceutical Technology department of the University of Basel, LASCCO AG and the support of the «Gerbert Rüf Stiftung» enabled us to further optimize and test our system to put a new gene therapy tool in place.

Publications

de Bruyn Ouboter, D., et al., Hierarchical Organization of Purely Peptidic Amphiphiles into Peptide Beads. The Journal of Physical Chemistry C, 2011. 115(30): p. 14583-14590;
Schuster, T.B., et al., Reversible peptide particle formation using a mini amino acid sequence. Soft Matter, 2010. 6(21): p. 5596-5604;
de Bruyn Ouboter, D., T. Schuster, V. Shanker, M. Heim and W. Meier, Multicompartment micelle-structured peptide nanoparticles: A new biocompatible gene- and drug-delivery tool, Journal of biomedical materials research. Part A, (2013), http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.34778/abstract;jsessionid=1093D850D32C79A7B91541B885E1399E.f01t02
D. de Bruyn Ouboter, T. B. Schuster, S. J. Sigg and W. P. Meier, Colloids and Surfaces B: Biointerfaces, 2013, 112, 542-547.

Revue de presse

Liens

http://www.chemie.unibas.ch/~meier/index.html
http://www.lascco.com

Personnes participant au projet

Prof. Wolfgang Meier, Universität Basel, Projektleiter wolfgang.notexisting@nodomain.commeier@unibas.notexisting@nodomain.comch
Prof. J. Huwyler, Pharmaceutical Technology, University Basel joerg.notexisting@nodomain.comhuwyler@unibas.notexisting@nodomain.comch
Viktoriia Postupalenko, Ph.D., Postdoctoral Researcher, Universität Basel viktoriia.notexisting@nodomain.compostupalenko@unibas.notexisting@nodomain.comch
Jason Duskey, Ph.D., Postdoctoral Researcher, Universität Basel jasonthomas.notexisting@nodomain.comduskey@unibas.notexisting@nodomain.comch
Severin Sigg, Ph.D. Student, Universität Basel s.notexisting@nodomain.comsigg@unibas.notexisting@nodomain.comch
Samareh Azeredo da Silveira Lajaunias, PhD, LASCCO SA, Geneva samareh.notexisting@nodomain.comlajaunias@lascco.notexisting@nodomain.comcom

Dernière mise à jour de cette présentation du projet  17.10.2018